Pathophysiological characterization of MERRF patient-specific induced neurons generated by direct reprogramming
نویسندگان
چکیده
منابع مشابه
Generation of patient-specific induced neuronal cells using a direct reprogramming strategy.
Direct reprogramming of human fibroblasts into functional neurons in vitro by defined factors provides an invaluable resource for regenerative medicine. However, clinical applications must consider the risk of immune rejection, thus patient-specific induced neuronal cells (iNCs) may serve as an ideal source for autologous cell replacement. In this study, we report a robust process for functiona...
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ژورنال
عنوان ژورنال: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
سال: 2019
ISSN: 0167-4889
DOI: 10.1016/j.bbamcr.2019.02.010